Traits

Traits linked to INTS8

integrator complex subunit 8

The Human Phenotype Ontology links 13 traits to INTS8, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Absent speech development	Always
Epilepsy	Always
Global developmental delay	Always
Inability to walk	Always
Periventricular nodular heterotopia	Always
Small cerebellum	Always

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Always
Prominent area between the eyebrows	Always

Abnormality of the eye

Trait	How often it is seen
Optic atrophy	Often (30–79%)
Wide-set eyes	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Overlapping toe	Always

Abnormality of the musculoskeletal system

Trait	How often it is seen
Spastic paraplegia	Always

Growth abnormality

Trait	How often it is seen
Short stature	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to INTS8 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test