Traits

Traits linked to HELLPAR

HELLP associated long non-coding RNA

The Human Phenotype Ontology links 29 traits to HELLPAR, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Low platelet count	Always
Hemolytic anemia	Very often (80–99%)
Hypofibrinogenemia	Often (30–79%)
Prolonged prothrombin time	Often (30–79%)
Decreased mean corpuscular hemoglobin concentration	Sometimes (5–29%)
Disseminated intravascular coagulation	Sometimes (5–29%)
Microangiopathic hemolytic anemia	Sometimes (5–29%)
Bleeding in brain	Rarely (1–4%)
Internal bleeding	Rarely (1–4%)

Laboratory abnormality

Trait	How often it is seen
High liver enzymes	Always
Generalized edema	Often (30–79%)
High urine protein levels	Often (30–79%)
Excess fluid in lungs	Sometimes (5–29%)
Fluid around lungs	Sometimes (5–29%)
Hemoglobin in urine	Sometimes (5–29%)
Increased circulating lactate dehydrogenase concentration	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Abdominal pain	Sometimes (5–29%)
Nausea	Sometimes (5–29%)
Vomiting	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Often (30–79%)
Epigastric pain	Sometimes (5–29%)
Shoulder pain	Sometimes (5–29%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Placental abruption	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Low blood pressure	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Acute kidney injury	Rarely (1–4%)

Abnormality of the integument

Trait	How often it is seen
Poor wound healing	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Back pain	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Headache	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Increased body weight	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to HELLPAR and how often each is seen. Find out more at hpo.jax.org.

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