Traits

Traits linked to CRH

corticotropin releasing hormone

The Human Phenotype Ontology links 21 traits to CRH, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Nocturnal seizures	Very often (80–99%)
Involuntary movements	Often (30–79%)
Paroxysmal dystonia	Often (30–79%)
Repetitive movements	Often (30–79%)
Anxiety	Sometimes (5–29%)
Cognitive impairment	Sometimes (5–29%)
Depression	Sometimes (5–29%)
EEG with focal spikes	Sometimes (5–29%)
Focal hyperkinetic seizure	Sometimes (5–29%)
Increased theta frequency activity in EEG	Sometimes (5–29%)
Interictal epileptiform activity	Sometimes (5–29%)
Sleep walking	Sometimes (5–29%)
Suicidal ideation	Sometimes (5–29%)
Attention deficit	Rarely (1–4%)
Behavioral abnormality	Rarely (1–4%)
Grand mal seizures	Rarely (1–4%)
Intellectual disability, mild	Rarely (1–4%)
NREM parasomnia	Rarely (1–4%)
Psychotic mentation	Rarely (1–4%)

Abnormality of the genitourinary system

Trait	How often it is seen
Loss of bladder control	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Rapid breathing	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CRH and how often each is seen. Find out more at hpo.jax.org.

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