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Gene

CACNA2D2

calcium voltage-gated channel auxiliary subunit alpha2delta 2

Summary

Cytogenetic location
3p21.31
Coordinates
Chromosome 3: 50,362,613–50,503,634 (GRCh38)
Exons
38 exons across 141 kb
Protein
1,143 amino acids
Also known as
KIAA0558, alpha2delta-2
MANE Select transcript
ENST00000424201.7NM_006030.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads CACNA2D2 yet. The test sequences your whole genome, so your data includes it all the same.

How CACNA2D2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where CACNA2D2 sits. CACNA2D2 and 25 genes near it on chromosome 3, from 49,933,124 to 50,933,123.Chromosome 33p21.31p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2950 Mb50.2 Mb50.4 Mb50.6 Mb50.8 MbRBM6: 49,940,007–50,100,045, forward strandRBM6RBM5: 50,088,898–50,119,021, forward strandRBM5SEMA3F: 50,155,012–50,189,075, forward strandSEMA3FGNAT1: 50,191,586–50,197,696, forward strandGNAT1SLC38A3: 50,202,871–50,221,504, forward strandSLC38A3GNAI2: 50,226,292–50,259,362, forward strandGNAI2SEMA3B: 50,267,507–50,277,573, forward strandLSMEM2: 50,279,030–50,288,116, forward strandIFRD2: 50,286,003–50,292,918, reverse strandIFRD2HYAL3: 50,292,830–50,299,437, reverse strandNAA80: 50,296,402–50,299,437, reverse strandHYAL1: 50,299,883–50,312,890, reverse strandHYAL2: 50,313,396–50,324,687, reverse strandHYAL2TUSC2: 50,320,027–50,328,251, reverse strandRASSF1: 50,329,782–50,340,980, reverse strandZMYND10: 50,341,110–50,345,746, reverse strandNPRL2: 50,347,330–50,350,826, reverse strandCYB561D2: 50,350,834–50,358,460, forward strandCYB561D2: 50,350,892–50,367,923, forward strandTMEM115: 50,352,820–50,359,566, reverse strandTMEM115CACNA2D2: 50,362,613–50,503,634, reverse strandCACNA2D2C3orf18: 50,556,409–50,573,568, reverse strandC3orf18HEMK1: 50,567,895–50,596,168, forward strandHEMK1CISH: 50,606,456–50,611,984, reverse strandCISHMAPKAPK3: 50,611,487–50,651,017, forward strandMAPKAPK3DOCK3: 50,674,875–51,384,198, forward strandDOCK3Diagram of CACNA2D2: 38 exons on the reverse strand of chromosome 3Exon 38: 1 known disease-causing siteExon 31: 1 known disease-causing siteExon 22: 1 known disease-causing siteExon 20: 1 known disease-causing siteExon 17: 1 known disease-causing siteExon 11: 2 known disease-causing sitesExon 8: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 1: 2 known disease-causing sitesExon 38: 50,362,613–50,364,806, 2,194 basesExon 37: 50,364,888–50,364,970, 83 basesExon 36: 50,365,075–50,365,184, 110 basesExon 35: 50,365,356–50,365,482, 127 basesExon 34: 50,365,633–50,365,688, 56 basesExon 33: 50,365,810–50,365,862, 53 basesExon 32: 50,366,011–50,366,163, 153 basesExon 31: 50,366,267–50,366,338, 72 basesExon 30: 50,366,578–50,366,625, 48 basesExon 29: 50,366,831–50,366,919, 89 basesExon 28: 50,367,011–50,367,109, 99 basesExon 27: 50,367,394–50,367,497, 104 basesExon 26: 50,367,642–50,367,704, 63 basesExon 25: 50,367,812–50,367,902, 91 basesExon 24: 50,368,138–50,368,235, 98 basesExon 23: 50,370,320–50,370,380, 61 basesExon 22: 50,374,737–50,374,813, 77 basesExon 21: 50,375,644–50,375,705, 62 basesExon 20: 50,375,809–50,375,880, 72 basesExon 19: 50,375,963–50,376,034, 72 basesExon 18: 50,376,114–50,376,188, 75 basesExon 17: 50,377,467–50,377,541, 75 basesExon 16: 50,377,732–50,377,803, 72 basesExon 15: 50,378,008–50,378,097, 90 basesExon 14: 50,378,284–50,378,333, 50 basesExon 13: 50,378,915–50,378,993, 79 basesExon 12: 50,379,092–50,379,199, 108 basesExon 11: 50,379,432–50,379,590, 159 basesExon 10: 50,379,725–50,379,824, 100 basesExon 9: 50,379,968–50,380,018, 51 basesExon 8: 50,380,748–50,380,805, 58 basesExon 7: 50,380,995–50,381,126, 132 basesExon 6: 50,384,196–50,384,337, 142 basesExon 5: 50,387,568–50,387,612, 45 basesExon 4: 50,394,109–50,394,168, 60 basesExon 3: 50,434,313–50,434,429, 117 basesExon 2: 50,476,118–50,476,199, 82 basesExon 1: 50,503,218–50,503,634, 417 bases382015′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.7 kb of the gene's 141 kb; 3,432 of those bases code for the protein.

How a genome test reads CACNA2D2

12

positions in CACNA2D2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 141 kb of CACNA2D2, introns included, not only the 5.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CACNA2D2 gene: calcium voltage-gated channel auxiliary subunit alpha2delta 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/cacna2d2

Vancouver

Dante Labs. CACNA2D2 gene: calcium voltage-gated channel auxiliary subunit alpha2delta 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cacna2d2

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