Traits

Traits linked to BCL6

BCL6 transcription repressor

The Human Phenotype Ontology links 17 traits to BCL6, by body system: features seen in people with one of the gene's rare conditions.

Laboratory abnormality

Trait	How often it is seen
Fever	Very often (80–99%)
Fluid around lungs	Sometimes (5–29%)
High blood calcium levels	Sometimes (5–29%)
Increased circulating lactate dehydrogenase concentration	Sometimes (5–29%)
Swelling caused by excess lymph fluid under skin	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Swollen lymph nodes	Very often (80–99%)
Swollen lymph nodes in center of chest	Very often (80–99%)
Increased spleen size	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Abnormal peritoneum morphology	Sometimes (5–29%)
Accumulation of fluid in the abdomen	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Often (30–79%)
Night sweats	Often (30–79%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Cancer of lymphatic system	Very often (80–99%)

Abnormality of the immune system

Trait	How often it is seen
Meningitis	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Skin nodule	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Mediastinal mass	Rarely (1–4%)

Growth abnormality

Trait	How often it is seen
Weight loss	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to BCL6 and how often each is seen. Find out more at hpo.jax.org.

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