Traits

Traits linked to ANK3

ankyrin 3

The Human Phenotype Ontology links 16 traits to ANK3, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Delayed speech and language development	Always
Difficulty sleeping	Always
Global developmental delay	Always
Intellectual disability	Always
IQ between 34 and 49	Always
Aggressive behavior	Often (30–79%)
Autism spectrum disorder	Often (30–79%)
Epilepsy	Often (30–79%)
More active than typical	Often (30–79%)
Teeth grinding	Often (30–79%)
Intellectual disability, mild	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Involuntary muscle stiffness, contraction, or spasm	Always
Low muscle tone	Always
Generalized decreased muscle tone	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Big calvaria	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Birth weight > 90th percentile	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ANK3 and how often each is seen. Find out more at hpo.jax.org.

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