Skip to content
Use your HSA or FSA funds

Trait

Premature sagging cheeks

Drooping or sinking of tissues of the cheeks more than would be expected at a given age. Sagging can occur due to a relative excess of skin and/or lack of elastic recoil as well as fat accumulation.

HPO HP:0034273

Summary

Also called
Premature facial sagging
Body system
Abnormality of head or neck

6 genes linked to Premature sagging cheeks

Changes in these genes cause rare conditions in which Premature sagging cheeks is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
AEBP1AE binding protein 1AlwaysIn 1 condition
ATP6V1E1ATPase H+ transporting V1 subunit E1AlwaysIn 1 condition
PYCR1pyrroline-5-carboxylate reductase 1AlwaysIn 1 condition
LTBP1latent transforming growth factor beta binding protein 1Very often (80–99%)In 1 condition
EMILIN1elastin microfibril interfacer 1Often (30–79%)In 1 condition
FBLN5fibulin 5Often (30–79%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of the cheek

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test