{
  "url": "https://dantelabs.com/traits/abnormal-pyramidal-tract-morphology",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-pyramidal-tract-morphology",
    "id": "HP:0002062",
    "name": "Abnormal pyramidal tract morphology",
    "definition": "Any structural abnormality of the pyramidal tract, whose chief element, the corticospinal tract, is the only direct connection between the brain and the spinal cord. In addition to the corticospinal tract, the pyramidal system includes the corticobulbar, corticomesencephalic, and corticopontine tracts.",
    "synonyms": [
      "Abnormality of the pyramidal tracts",
      "Morphological abnormality of the pyramidal tract"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "morphological-central-nervous-system-abnormality",
        "name": "Morphological central nervous system abnormality",
        "url": "https://dantelabs.com/traits/morphological-central-nervous-system-abnormality"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-corticospinal-tract-morphology",
        "name": "Abnormal corticospinal tract morphology",
        "genes": 6,
        "url": "https://dantelabs.com/traits/abnormal-corticospinal-tract-morphology"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-pyramidal-tract",
        "name": "Aplasia/Hypoplasia of the pyramidal tract",
        "genes": 1,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-pyramidal-tract"
      }
    ],
    "genes": [
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "hgnc": "HGNC:8768",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aifm1"
      },
      {
        "slug": "prnp",
        "symbol": "PRNP",
        "hgnc": "HGNC:9449",
        "name": "prion protein (Kanno blood group)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prnp"
      },
      {
        "slug": "galc",
        "symbol": "GALC",
        "hgnc": "HGNC:4115",
        "name": "galactosylceramidase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galc"
      },
      {
        "slug": "atxn10",
        "symbol": "ATXN10",
        "hgnc": "HGNC:10549",
        "name": "ataxin 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn10"
      },
      {
        "slug": "atxn8",
        "symbol": "ATXN8",
        "hgnc": "HGNC:32925",
        "name": "ataxin 8",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn8"
      },
      {
        "slug": "atxn8os",
        "symbol": "ATXN8OS",
        "hgnc": "HGNC:10561",
        "name": "ATXN8 opposite strand lncRNA",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn8os"
      },
      {
        "slug": "ctc1",
        "symbol": "CTC1",
        "hgnc": "HGNC:26169",
        "name": "CST telomere replication complex component 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctc1"
      },
      {
        "slug": "dpys",
        "symbol": "DPYS",
        "hgnc": "HGNC:3013",
        "name": "dihydropyrimidinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dpys"
      },
      {
        "slug": "fxn",
        "symbol": "FXN",
        "hgnc": "HGNC:3951",
        "name": "frataxin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fxn"
      },
      {
        "slug": "gan",
        "symbol": "GAN",
        "hgnc": "HGNC:4137",
        "name": "gigaxonin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gan"
      },
      {
        "slug": "kcnc3",
        "symbol": "KCNC3",
        "hgnc": "HGNC:6235",
        "name": "potassium voltage-gated channel subfamily C member 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnc3"
      },
      {
        "slug": "l2hgdh",
        "symbol": "L2HGDH",
        "hgnc": "HGNC:20499",
        "name": "L-2-hydroxyglutarate dehydrogenase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/l2hgdh"
      },
      {
        "slug": "mapt",
        "symbol": "MAPT",
        "hgnc": "HGNC:6893",
        "name": "microtubule associated protein tau",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mapt"
      },
      {
        "slug": "pla2g6",
        "symbol": "PLA2G6",
        "hgnc": "HGNC:9039",
        "name": "phospholipase A2 group VI",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pla2g6"
      },
      {
        "slug": "prkra",
        "symbol": "PRKRA",
        "hgnc": "HGNC:9438",
        "name": "protein activator of interferon induced protein kinase EIF2AK2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkra"
      },
      {
        "slug": "slc19a3",
        "symbol": "SLC19A3",
        "hgnc": "HGNC:16266",
        "name": "solute carrier family 19 member 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc19a3"
      },
      {
        "slug": "slc2a1",
        "symbol": "SLC2A1",
        "hgnc": "HGNC:11005",
        "name": "solute carrier family 2 member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc2a1"
      },
      {
        "slug": "slc6a3",
        "symbol": "SLC6A3",
        "hgnc": "HGNC:11049",
        "name": "solute carrier family 6 member 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc6a3"
      },
      {
        "slug": "trex1",
        "symbol": "TREX1",
        "hgnc": "HGNC:12269",
        "name": "three prime repair exonuclease 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trex1"
      },
      {
        "slug": "vapb",
        "symbol": "VAPB",
        "hgnc": "HGNC:12649",
        "name": "VAMP associated protein B and C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vapb"
      }
    ]
  }
}