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Trait

Abnormal pineal melatonin secretion

An anomaly in the amount or timing of melatonin secretion by the pineal gland. Note that melatonin is also synthesized by multiple tissues outside of the pineal gland.

HPO HP:0012689

Summary

Body system
Abnormality of the endocrine systemAbnormality of the nervous system

6 genes linked to Abnormal pineal melatonin secretion

Changes in these genes cause rare conditions in which Abnormal pineal melatonin secretion is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
RAI1retinoic acid induced 1Very often (80–99%)In 1 condition
ABCB11ATP binding cassette subfamily B member 11Sometimes (5–29%)In 1 condition
ABCB4ATP binding cassette subfamily B member 4Sometimes (5–29%)In 1 condition
ATP8B1ATPase phospholipid transporting 8B1Sometimes (5–29%)In 1 condition
NR1H4nuclear receptor subfamily 1 group H member 4Sometimes (5–29%)In 1 condition
PRNPprion protein (Kanno blood group)Sometimes (5–29%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of pineal physiology

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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