Traits

Traits linked to TP73

tumor protein p73

The Human Phenotype Ontology links 10 traits to TP73, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Fewer or absent grooves in brain	Always
Epilepsy	Sometimes (5–29%)
Agenesis of corpus callosum	Not recorded
Underdevelopment of part of brain called corpus callosum	Not recorded

Abnormality of the respiratory system

Trait	How often it is seen
Breathing difficulties	Very often (80–99%)
Abnormal mucociliary clearance	Not recorded
Partial or complete collapse of part or entire lung	Not recorded
Permanent enlargement of the airways of the lungs	Not recorded

Abnormality of the ear

Trait	How often it is seen
Chronic infections of the middle ear	Not recorded

Abnormality of the immune system

Trait	How often it is seen
Recurrent respiratory infections	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TP73 and how often each is seen. Find out more at hpo.jax.org.

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