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Gene

TNFRSF10B

TNF receptor superfamily member 10b

Summary

Cytogenetic location
8p21.3
Coordinates
Chromosome 8: 23,020,133–23,069,031 (GRCh38)
Exons
9 exons across 48.9 kb
Protein
440 amino acids
Also known as
DR5, KILLER, TRICK2A, TRAIL-R2, TRICKB, CD262, TRAILR2
MANE Select transcript
ENST00000276431.9NM_003842.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TNFRSF10B yet. The test sequences your whole genome, so your data includes it all the same.

How TNFRSF10B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 8, with a bracket where TNFRSF10B sits. TNFRSF10B and 19 genes near it on chromosome 8, from 22,544,582 to 23,544,581.Chromosome 88p21.3p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.322.6 Mb22.8 Mb23 Mb23.2 Mb23.4 MbPPP3CC: 22,440,746–22,544,727, forward strandPPP3CCSORBS3: 22,544,986–22,575,788, forward strandPDLIM2: 22,578,058–22,598,025, forward strand: 22,589,274–22,602,084, forward strandC8orf58: 22,599,588–22,604,271, forward strandC8orf58CCAR2: 22,604,629–22,620,964, forward strandCCAR2BIN3: 22,610,290–22,669,148, reverse strandBIN3EGR3: 22,687,659–22,693,480, reverse strandEGR3PEBP4: 22,710,102–23,000,000, reverse strandPEBP4RHOBTB2: 22,987,222–23,020,723, forward strandRHOBTB2TNFRSF10B: 23,020,133–23,069,031, reverse strandTNFRSF10B: 23,084,403–23,115,536, forward strandTNFRSF10C: 23,102,921–23,122,014, forward strandTNFRSF10CTNFRSF10D: 23,135,588–23,164,030, reverse strandTNFRSF10DTNFRSF10A: 23,183,123–23,225,145, reverse strandTNFRSF10ACHMP7: 23,243,630–23,266,156, forward strandCHMP7R3HCC1: 23,270,120–23,296,279, forward strandR3HCC1LOXL2: 23,296,897–23,425,328, reverse strandLOXL2ENTPD4: 23,385,783–23,457,722, reverse strandENTPD4SLC25A37: 23,528,859–23,654,350, forward strandSLC25A37Diagram of TNFRSF10B: 9 exons on the reverse strand of chromosome 8Exon 5: 1 known disease-causing siteExon 9: 23,020,133–23,022,984, 2,852 basesExon 8: 23,024,188–23,024,260, 73 basesExon 7: 23,027,133–23,027,288, 156 basesExon 6: 23,027,722–23,027,753, 32 basesExon 5: 23,028,331–23,028,602, 272 basesExon 4: 23,029,610–23,029,721, 112 basesExon 3: 23,030,759–23,030,872, 114 basesExon 2: 23,043,138–23,043,243, 106 basesExon 1: 23,068,751–23,069,031, 281 bases9864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4 kb of the gene's 48.9 kb; 1,323 of those bases code for the protein.

How a genome test reads TNFRSF10B

1

position in TNFRSF10B where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 48.9 kb of TNFRSF10B, introns included, not only the 4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TNFRSF10B gene: TNF receptor superfamily member 10b. Retrieved 16 October 2026, from https://dantelabs.com/genes/tnfrsf10b

Vancouver

Dante Labs. TNFRSF10B gene: TNF receptor superfamily member 10b [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tnfrsf10b

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