Traits

Traits linked to SRP19

signal recognition particle 19

The Human Phenotype Ontology links 31 traits to SRP19, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Low blood neutrophil count	Always
Decreased blood lymphocyte number	Often (30–79%)
High blood monocyte number	Often (30–79%)
Acute lymphoblastic leukemia	Sometimes (5–29%)
Acute myeloid leukemia	Sometimes (5–29%)
Aplastic anemia	Sometimes (5–29%)
Blood cancer	Sometimes (5–29%)
High blood eosinophil count	Sometimes (5–29%)
Myelodysplasia	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Recurrent bacterial infections	Very often (80–99%)
Recurrent viral infections	Very often (80–99%)
Pneumonia	Often (30–79%)
Recurrent ear infections	Often (30–79%)
Recurrent sinus and lung infections	Often (30–79%)
Recurrent skin infections	Often (30–79%)
Antineutrophil antibody positivity	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Gum disease	Often (30–79%)
Inflamed gums	Often (30–79%)
Mouth sore	Often (30–79%)
Nasal inflammation	Often (30–79%)
Recurrent canker sores	Often (30–79%)
Early tooth loss	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Abdominal pain	Often (30–79%)
Diarrhea	Often (30–79%)
Recurrent infection of the gastrointestinal tract	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Bacterial infection of skin	Sometimes (5–29%)
Osteopenia	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Strawberry mark	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Pyoderma gangrenosum	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Pharyngitis	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Fever	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SRP19 and how often each is seen. Find out more at hpo.jax.org.

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