Traits

Traits linked to SPARC

secreted protein acidic and cysteine rich

The Human Phenotype Ontology links 20 traits to SPARC, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the musculoskeletal system

Trait	How often it is seen
Compression fracture of a vertebral body	Always
Double-Jointed	Always
Kyphoscoliosis	Always
Low solidness and mass of the bones	Always
Osteoporosis	Always
Recurrent fractures	Always
Decreased muscle mass	Often (30–79%)
Flattened vertebrae	Often (30–79%)
Low muscle tone	Often (30–79%)
Muscle weakness	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Bowed long bone in upper arm	Often (30–79%)
Hip dislocation	Often (30–79%)
Thin metacarpal cortices	Often (30–79%)
Thin shaft of long bone	Often (30–79%)

Abnormality of the nervous system

Trait	How often it is seen
Delayed motor skills	Often (30–79%)
Delayed speech and language development	Often (30–79%)
Fluid-filled cyst in spinal cord	Often (30–79%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Intraventricular hemorrhage	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Soft skin	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Short stature	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SPARC and how often each is seen. Find out more at hpo.jax.org.

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