Traits

Traits linked to SNAP25

synaptosome associated protein 25

The Human Phenotype Ontology links 13 traits to SNAP25, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Abnormal gait	Always
Absent reflexes	Always
Ataxia	Always
Delayed ability to walk	Always
Difficulty articulating speech	Always
Echoing another person's speech	Always
Global developmental delay	Always
Poor speech	Always

Abnormality of limbs

Trait	How often it is seen
Inability to straighten knee	Always

Abnormality of prenatal development or birth

Trait	How often it is seen
Less than 10 fetal movements in 12 hours	Always

Abnormality of the eye

Trait	How often it is seen
Drooping upper eyelid	Always

Abnormality of the musculoskeletal system

Trait	How often it is seen
Fatigable weakness	Always

Abnormality of the respiratory system

Trait	How often it is seen
Neonatal respiratory distress	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SNAP25 and how often each is seen. Find out more at hpo.jax.org.

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