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Gene

SLC6A4

solute carrier family 6 member 4

Summary

Cytogenetic location
17q11.2
Coordinates
Chromosome 17: 30,194,319–30,235,697 (GRCh38)
Exons
15 exons across 41.4 kb
Protein
630 amino acids
Also known as
5-HTT, SERT1
Previous symbols
HTT, OCD1
MANE Select transcript
ENST00000650711.1NM_001045.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SLC6A4 yet. The test sequences your whole genome, so your data includes it all the same.

How SLC6A4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where SLC6A4 sits. SLC6A4 and 7 genes near it on chromosome 17, from 29,715,008 to 30,715,007.Chromosome 1717q11.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.329.8 Mb30 Mb30.2 Mb30.4 Mb30.6 MbSSH2: 29,625,938–29,930,276, reverse strandSSH2EFCAB5: 29,929,200–30,108,452, forward strandEFCAB5NSRP1: 30,115,521–30,186,475, forward strandNSRP1SLC6A4: 30,194,319–30,235,697, reverse strandSLC6A4BLMH: 30,248,193–30,292,152, reverse strandBLMHTMIGD1: 30,310,988–30,334,098, reverse strandTMIGD1CPD: 30,378,545–30,469,989, forward strandCPDGOSR1: 30,477,362–30,528,309, forward strandGOSR1Diagram of SLC6A4: 15 exons on the reverse strand of chromosome 17Exon 14: 1 known disease-causing siteExon 15: 30,194,319–30,198,530, 4,212 basesExon 14: 30,203,172–30,203,339, 168 basesExon 13: 30,207,732–30,207,832, 101 basesExon 12: 30,209,143–30,209,242, 100 basesExon 11: 30,210,515–30,210,646, 132 basesExon 10: 30,211,312–30,211,424, 113 basesExon 9: 30,212,740–30,212,867, 128 basesExon 8: 30,215,611–30,215,714, 104 basesExon 7: 30,216,082–30,216,216, 135 basesExon 6: 30,217,166–30,217,304, 139 basesExon 5: 30,218,118–30,218,337, 220 basesExon 4: 30,218,797–30,218,931, 135 basesExon 3: 30,221,616–30,222,081, 466 basesExon 2: 30,222,819–30,222,915, 97 basesExon 1: 30,235,613–30,235,697, 85 bases15141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.3 kb of the gene's 41.4 kb; 1,893 of those bases code for the protein.

How a genome test reads SLC6A4

1

position in SLC6A4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 41.4 kb of SLC6A4, introns included, not only the 6.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SLC6A4 gene: solute carrier family 6 member 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/slc6a4

Vancouver

Dante Labs. SLC6A4 gene: solute carrier family 6 member 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/slc6a4

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