Traits

Traits linked to SLC27A4

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The Human Phenotype Ontology links 19 traits to SLC27A4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the integument

Trait	How often it is seen
Follicular hyperkeratosis	Always
Generalized ichthyosis	Always
Itching	Always
Thickening of upper layer of skin	Always
Ichthyosis	Very often (80–99%)
Patchy darkened skin	Not recorded

Abnormality of prenatal development or birth

Trait	How often it is seen
Caseous vernix-like desquamation	Always
High levels of amniotic fluid	Always
Premature birth	Always
Desquamation of skin soon after birth	Very often (80–99%)

Abnormality of the immune system

Trait	How often it is seen
Red scaly skin caused by inflammatory skin disease	Always
Asthma	Sometimes (5–29%)
Food allergy	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Absence of scalp hair	Sometimes (5–29%)
Hay fever	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Neonatal asphyxia	Always
Neonatal respiratory distress	Very often (80–99%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
High blood eosinophil count	Very often (80–99%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Skin writing	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SLC27A4 and how often each is seen. Find out more at hpo.jax.org.

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