Traits

Traits linked to MARCHF6

membrane associated ring-CH-type finger 6

The Human Phenotype Ontology links 15 traits to MARCHF6, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
EEG abnormality	Very often (80–99%)
Hand tremor	Very often (80–99%)
Jerking	Very often (80–99%)
Tremor	Very often (80–99%)
Generalized-onset seizure	Often (30–79%)
Seizure affecting one half of brain	Often (30–79%)
Headache	Sometimes (5–29%)
Intellectual disability	Sometimes (5–29%)
Abnormal gait	Not recorded
EEG with photoparoxysmal response	Not recorded
Enhancement of the C-reflex	Not recorded
Giant somatosensory evoked potentials	Not recorded
Grand mal seizures	Not recorded
Jerk-locked premyoclonus spikes	Not recorded

Abnormality of the eye

Trait	How often it is seen
Amaurosis fugax	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to MARCHF6 and how often each is seen. Find out more at hpo.jax.org.

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