Traits

Traits linked to HNRNPH2

heterogeneous nuclear ribonucleoprotein H2

The Human Phenotype Ontology links 50 traits to HNRNPH2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Always
Intellectual disability	Always
Anxiety	Often (30–79%)
Attention deficit	Often (30–79%)
Autism spectrum disorder	Often (30–79%)
Epilepsy	Often (30–79%)
Loss of developmental milestones	Often (30–79%)
Abnormal gait	Sometimes (5–29%)
Absent speech development	Sometimes (5–29%)
Aggressive behavior	Sometimes (5–29%)
Ataxia	Sometimes (5–29%)
Conspicuously happy disposition	Sometimes (5–29%)
Obsessive compulsive behavior	Sometimes (5–29%)
Recurrent hand flapping	Sometimes (5–29%)
Repetitive movements	Sometimes (5–29%)
Self-injurious behavior	Sometimes (5–29%)
Small cerebellum	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Development of small head that was not present at birth	Often (30–79%)
High palate	Often (30–79%)
Low hanging columella	Often (30–79%)
Short philtrum	Often (30–79%)
Underdeveloped tissue around nostril	Often (30–79%)
Almond shaped eyes	Sometimes (5–29%)
Drooling	Sometimes (5–29%)
Eye folds	Sometimes (5–29%)
Full lips	Sometimes (5–29%)
Little lower jaw	Sometimes (5–29%)
Midface retrusion	Sometimes (5–29%)
Short opening between the eyelids	Sometimes (5–29%)
Wide mouth	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Always
Double-Jointed	Sometimes (5–29%)
Pigeon chest	Sometimes (5–29%)
Prominent swayback	Sometimes (5–29%)
Scoliosis	Sometimes (5–29%)
Spasticity and rigidity of muscles	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Dropped arches	Often (30–79%)
Long slender fingers	Sometimes (5–29%)
Prominent fingertip pads	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Acid reflux	Often (30–79%)
Feeding difficulties	Often (30–79%)
Chronic constipation	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Abnormally close eyes	Sometimes (5–29%)
Outward facing eye ball	Sometimes (5–29%)
Wide-set eyes	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Mitral valve prolapse	Often (30–79%)
An opening in the wall separating the top two chambers of the heart	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Often (30–79%)
Short stature	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Curly hair	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to HNRNPH2 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test