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Gene

HLA-E

major histocompatibility complex, class I, E

Summary

Cytogenetic location
6p22.1
Coordinates
Chromosome 6: 30,489,509–30,494,194 (GRCh38)
Exons
8 exons across 4.7 kb
Protein
358 amino acids
MANE Select transcript
ENST00000376630.5NM_005516.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads HLA-E yet. The test sequences your whole genome, so your data includes it all the same.

How HLA-E is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 6, with a bracket where HLA-E sits. HLA-E and 32 genes near it on chromosome 6, from 29,991,852 to 30,991,851.Chromosome 66p22.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2730 Mb30.2 Mb30.4 Mb30.6 Mb30.8 MbPOLR1H: 30,058,899–30,064,909, forward strandPOLR1HPPP1R11: 30,066,709–30,074,025, forward strandPPP1R11RNF39: 30,070,266–30,075,849, reverse strandRNF39TRIM31: 30,102,886–30,113,126, reverse strandTRIM31TRIM40: 30,136,028–30,151,592, forward strandTRIM40TRIM10: 30,151,943–30,161,288, reverse strandTRIM10TRIM15: 30,163,194–30,173,160, forward strandTRIM15TRIM26: 30,184,446–30,214,158, reverse strandTRIM26TRIM39: 30,325,880–30,344,265, forward strandTRIM39TRIM39-RPP21: 30,328,907–30,346,854, forward strandTRIM39-RPP21RPP21: 30,345,125–30,346,884, forward strandRPP21HLA-E: 30,489,509–30,494,194, forward strandHLA-EGNL1: 30,541,212–30,556,603, reverse strandGNL1PRR3: 30,556,704–30,563,723, forward strandPRR3ABCF1: 30,571,383–30,597,179, forward strandABCF1PPP1R10: 30,600,400–30,618,612, reverse strandPPP1R10MRPS18B: 30,617,759–30,626,398, forward strandMRPS18BATAT1: 30,626,837–30,646,835, forward strandATAT1C6orf136: 30,647,003–30,653,225, forward strandC6orf136DHX16: 30,652,469–30,673,059, reverse strandPPP1R18: 30,676,389–30,687,895, reverse strandNRM: 30,688,047–30,691,420, reverse strandNRMMDC1: 30,699,807–30,717,562, reverse strandMDC1TUBB: 30,717,435–30,725,538, forward strandTUBBFLOT1: 30,727,709–30,743,075, reverse strandFLOT1IER3: 30,743,199–30,744,555, reverse strandIER3DDR1: 30,876,421–30,900,978, forward strandDDR1GTF2H4: 30,907,517–30,914,119, forward strandGTF2H4VARS2: 30,914,205–30,928,614, forward strandVARS2SFTA2: 30,931,353–30,955,636, reverse strandSFTA2SFTA2-AS1: 30,934,523–30,938,824, forward strandSFTA2-AS1MUCL3: 30,940,973–30,954,221, forward strandMUC21: 30,983,718–30,989,903, forward strandMUC21Diagram of HLA-E: 8 exons on the forward strand of chromosome 6Exon 1: 30,489,509–30,489,595, 87 basesExon 2: 30,489,726–30,489,995, 270 basesExon 3: 30,490,240–30,490,515, 276 basesExon 4: 30,491,137–30,491,412, 276 basesExon 5: 30,491,537–30,491,653, 117 basesExon 6: 30,492,404–30,492,436, 33 basesExon 7: 30,492,541–30,492,583, 43 basesExon 8: 30,492,749–30,494,194, 1,446 bases123456785′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.5 kb of the gene's 4.7 kb; 1,077 of those bases code for the protein.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). HLA-E gene: major histocompatibility complex, class I, E. Retrieved 17 October 2026, from https://dantelabs.com/genes/hla-e

Vancouver

Dante Labs. HLA-E gene: major histocompatibility complex, class I, E [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hla-e

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