Traits

Traits linked to FRA16E

fragile site, distamycin A type, rare, fra(16)(p12.1)

The Human Phenotype Ontology links 9 traits to FRA16E, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Delayed speech and language development	Always
Global developmental delay	Always
Behavioral abnormality	Often (30–79%)
Epilepsy	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Abnormal facial shape	Very often (80–99%)
Abnormally small head	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Underdeveloped left heart	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Growth delay	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to FRA16E and how often each is seen. Find out more at hpo.jax.org.

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