Traits

Traits linked to EIF2B2

eukaryotic translation initiation factor 2B subunit beta

The Human Phenotype Ontology links 9 traits to EIF2B2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Leukoencephalopathy	Always
Memory impairment	Always
Unsteady walk	Always
Difficulty articulating speech	Often (30–79%)

Abnormality of the genitourinary system

Trait	How often it is seen
Early menopause	Always
Previous menstrual periods stop	Always

Abnormality of limbs

Trait	How often it is seen
Lower limb muscle weakness	Always

Abnormality of the eye

Trait	How often it is seen
Clouding of the lens of the eye	Always

Abnormality of the musculoskeletal system

Trait	How often it is seen
Involuntary muscle stiffness, contraction, or spasm	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to EIF2B2 and how often each is seen. Find out more at hpo.jax.org.

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