Traits

Traits linked to ACAD8

acyl-CoA dehydrogenase family member 8

The Human Phenotype Ontology links 12 traits to ACAD8, by body system: features seen in people with one of the gene's rare conditions.

Laboratory abnormality

Trait	How often it is seen
Elevated circulating fatty acylcarnitine concentration	Often (30–79%)
Elevated urinary dicarboxylic acid level	Often (30–79%)
Dehydration	Sometimes (5–29%)
Ketotic hypoglycemia	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Narrowing of pulmonic valve	Sometimes (5–29%)
Stretched and thinned heart muscle	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Delayed speech and language development	Sometimes (5–29%)
Mild global developmental delay	Sometimes (5–29%)

Abnormal cellular phenotype

Trait	How often it is seen
Carnitine deficiency	Often (30–79%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Low number of red blood cells or hemoglobin	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Vomiting	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ACAD8 and how often each is seen. Find out more at hpo.jax.org.

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