Trait

Hyperconvex fingernails

When viewed on end (with the finger tip pointing toward the examiner's eye) the curve of the fingernail forms a tighter curve of convexity.

HPO HP:0001812

Also called: Tubular fingernails
Body system: Abnormality of the integument

This page as data

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library(jsonlite)

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page <- fromJSON(url)
page$trait$name

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9 genes linked to Hyperconvex fingernails

Changes in these genes cause rare conditions in which Hyperconvex fingernails is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
PLECplectin	Very often (80–99%)	In 1 condition
MBTPS2membrane bound transcription factor peptidase, site 2	Often (30–79%)	In 1 condition
RPS6KA3ribosomal protein S6 kinase A3	Often (30–79%)	In 2 conditions
PTDSS1phosphatidylserine synthase 1	Sometimes (5–29%)	In 1 condition
CPLX1complexin 1	Not recorded	In 1 condition
CTBP1C-terminal binding protein 1	Not recorded	In 1 condition
FGFRL1fibroblast growth factor receptor like 1	Not recorded	In 1 condition
LETM1leucine zipper and EF-hand containing transmembrane protein 1	Not recorded	In 1 condition
NSD2nuclear receptor binding SET domain protein 2	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Increased nail curvature

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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