{
  "url": "https://dantelabs.com/traits/bile-duct-proliferation",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "bile-duct-proliferation",
    "id": "HP:0001408",
    "name": "Bile duct proliferation",
    "definition": "Proliferative changes of the bile ducts.",
    "synonyms": [
      "Proliferation of bile canaliculi"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-biliary-tract-morphology",
        "name": "Abnormal biliary tract morphology",
        "url": "https://dantelabs.com/traits/abnormal-biliary-tract-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "abcb4",
        "symbol": "ABCB4",
        "hgnc": "HGNC:45",
        "name": "ATP binding cassette subfamily B member 4",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/abcb4"
      },
      {
        "slug": "cyp7b1",
        "symbol": "CYP7B1",
        "hgnc": "HGNC:2652",
        "name": "cytochrome P450 family 7 subfamily B member 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cyp7b1"
      },
      {
        "slug": "farsb",
        "symbol": "FARSB",
        "hgnc": "HGNC:17800",
        "name": "phenylalanyl-tRNA synthetase subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/farsb"
      },
      {
        "slug": "micos13",
        "symbol": "MICOS13",
        "hgnc": "HGNC:33702",
        "name": "mitochondrial contact site and cristae organizing system subunit 13",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/micos13"
      },
      {
        "slug": "pskh1",
        "symbol": "PSKH1",
        "hgnc": "HGNC:9529",
        "name": "protein serine kinase H1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pskh1"
      },
      {
        "slug": "rpgrip1l",
        "symbol": "RPGRIP1L",
        "hgnc": "HGNC:29168",
        "name": "RPGRIP1 like",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rpgrip1l"
      },
      {
        "slug": "slc37a4",
        "symbol": "SLC37A4",
        "hgnc": "HGNC:4061",
        "name": "solute carrier family 37 member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc37a4"
      },
      {
        "slug": "kif12",
        "symbol": "KIF12",
        "hgnc": "HGNC:21495",
        "name": "kinesin family member 12",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif12"
      },
      {
        "slug": "tmem216",
        "symbol": "TMEM216",
        "hgnc": "HGNC:25018",
        "name": "transmembrane protein 216",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem216"
      },
      {
        "slug": "abcb11",
        "symbol": "ABCB11",
        "hgnc": "HGNC:42",
        "name": "ATP binding cassette subfamily B member 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcb11"
      },
      {
        "slug": "atp8b1",
        "symbol": "ATP8B1",
        "hgnc": "HGNC:3706",
        "name": "ATPase phospholipid transporting 8B1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp8b1"
      },
      {
        "slug": "cldn1",
        "symbol": "CLDN1",
        "hgnc": "HGNC:2032",
        "name": "claudin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cldn1"
      },
      {
        "slug": "dcdc2",
        "symbol": "DCDC2",
        "hgnc": "HGNC:18141",
        "name": "doublecortin domain containing 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dcdc2"
      },
      {
        "slug": "phkg2",
        "symbol": "PHKG2",
        "hgnc": "HGNC:8931",
        "name": "phosphorylase kinase catalytic subunit gamma 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phkg2"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "tmem67",
        "symbol": "TMEM67",
        "hgnc": "HGNC:28396",
        "name": "transmembrane protein 67",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tmem67"
      },
      {
        "slug": "hsd17b4",
        "symbol": "HSD17B4",
        "hgnc": "HGNC:5213",
        "name": "hydroxysteroid 17-beta dehydrogenase 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsd17b4"
      },
      {
        "slug": "ift56",
        "symbol": "IFT56",
        "hgnc": "HGNC:21882",
        "name": "intraflagellar transport 56",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift56"
      },
      {
        "slug": "med12",
        "symbol": "MED12",
        "hgnc": "HGNC:11957",
        "name": "mediator complex subunit 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med12"
      },
      {
        "slug": "cc2d2a",
        "symbol": "CC2D2A",
        "hgnc": "HGNC:29253",
        "name": "coiled-coil and C2 domain containing 2A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cc2d2a"
      },
      {
        "slug": "cep290",
        "symbol": "CEP290",
        "hgnc": "HGNC:29021",
        "name": "centrosomal protein 290",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep290"
      },
      {
        "slug": "mks1",
        "symbol": "MKS1",
        "hgnc": "HGNC:7121",
        "name": "MKS transition zone complex subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mks1"
      },
      {
        "slug": "nphp3",
        "symbol": "NPHP3",
        "hgnc": "HGNC:7907",
        "name": "nephrocystin 3",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nphp3"
      },
      {
        "slug": "wdr35",
        "symbol": "WDR35",
        "hgnc": "HGNC:29250",
        "name": "WD repeat domain 35",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr35"
      }
    ]
  }
}