Wolfram syndrome
Autosomal recessive
Progressive childhood-onset diabetes and optic atrophy, often with diabetes insipidus, hearing loss and neurological features (WFS1, CISD2).
What a diagnosis changes
Diagnosis guides diabetes care and allows planned eye, hearing, urinary and neurological follow-up.
Also known as
diabetes insipidus, diabetes mellitus, optic atrophy, and deafness syndrome; diabetes insipidus-diabetes mellitus-optic atrophy-deafness syndrome; diabetes mellitus and insipidus with optic atrophy and deafness; DIDMOAD; DIDMOAD syndrome
Includes 3 related subtypes ↓Hide subtypes ↑
- Wolfram syndrome 1
- Wolfram syndrome 2
- Wolfram syndrome, mitochondrial form
