Traits

Traits linked to VWF

von Willebrand factor

The Human Phenotype Ontology links 19 traits to VWF, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Reduced factor VIII activity	Always
Reduced von Willebrand factor activity	Always
Bloody nose	Often (30–79%)
Bruising susceptibility	Often (30–79%)
Excessive bleeding after minor trauma	Often (30–79%)
Prolonged bleeding after dental extraction	Often (30–79%)
Prolonged bleeding after surgery	Often (30–79%)
Bleeding within a joint	Sometimes (5–29%)
Abnormally heavy bleeding during menstruation	Not recorded
Bleeding tendency	Not recorded
Gastrointestinal bleeding	Not recorded
Impaired platelet aggregation	Not recorded
Low platelet count	Not recorded
Prolonged bleeding time	Not recorded
Prolonged whole-blood clotting time	Not recorded
Reduced quantity of Von Willebrand factor	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Gastrointestinal angiodysplasia	Not recorded
Mitral valve prolapse	Not recorded
Narrowing of aortic valve	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to VWF and how often each is seen. Find out more at hpo.jax.org.

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