Traits

Traits linked to TPM4

tropomyosin 4

The Human Phenotype Ontology links 15 traits to TPM4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Bruising susceptibility	Always
Impaired collagen-induced platelet aggregation	Always
Large platelets	Always
Abnormally heavy bleeding during menstruation	Very often (80–99%)
Low platelet count	Very often (80–99%)
Macrothrombocytopenia	Very often (80–99%)
Bleeding post-delivery	Often (30–79%)
Excessive bleeding from superficial cuts	Often (30–79%)
Impaired ADP-induced platelet aggregation	Often (30–79%)
Platelet anisocytosis	Often (30–79%)
Prolonged bleeding after dental extraction	Often (30–79%)
Recurring nosebleed	Often (30–79%)
Bloody nose	Sometimes (5–29%)
Prolonged bleeding after surgery	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormal uterus bleeding	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TPM4 and how often each is seen. Find out more at hpo.jax.org.

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