Skip to content
Use your HSA or FSA funds

Gene

CYP4F2

cytochrome P450 family 4 subfamily F member 2

Summary

Cytogenetic location
19p13.12
Coordinates
Chromosome 19: 15,878,023–15,898,074 (GRCh38)
Exons
13 exons across 20.1 kb
Protein
520 amino acids
MANE Select transcript
ENST00000221700.11NM_001082.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

CYP4F2 and medicines

  • Warfarin dose requirement

    Pharmacogenomics

    CYP4F2 removes vitamin K from circulation. The *3 allele leaves more vitamin K available, so carriers typically need a slightly higher warfarin dose to reach the same effect.

    • Only meaningful as one input into a warfarin dosing algorithm, alongside CYP2C9 and VKORC1.

    Alleles the report reads

    • *1
    • *3
    MedicineCPIC levelGuideline
    warfarinACYP2C9, VKORC1, CYP4F2 and Warfarin
    acenocoumarolB
    phenprocoumonB

How CYP4F2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 19, with a bracket where CYP4F2 sits. CYP4F2 and 22 genes near it on chromosome 19, from 15,388,049 to 16,388,048.Chromosome 1919p13.12p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4315.4 Mb15.6 Mb15.8 Mb16 Mb16.2 MbAKAP8L: 15,380,046–15,419,141, reverse strandAKAP8LWIZ: 15,419,978–15,450,038, reverse strandWIZRASAL3: 15,451,624–15,464,583, reverse strandRASAL3PGLYRP2: 15,468,625–15,498,956, reverse strandPGLYRP2CYP4F22: 15,508,477–15,552,317, forward strandCYP4F22CYP4F8: 15,615,218–15,630,639, forward strandCYP4F8CYP4F3: 15,640,795–15,662,825, forward strandCYP4F3CYP4F12: 15,673,018–15,698,819, forward strandCYP4F12OR10H2: 15,728,024–15,729,052, forward strandOR10H2OR10H3: 15,737,985–15,742,343, forward strandOR10H3OR10H5: 15,787,661–15,800,357, forward strandOR10H5OR10H1: 15,804,549–15,815,664, reverse strandOR10H1CYP4F2: 15,878,023–15,898,074, reverse strandCYP4F2CYP4F11: 15,912,367–15,934,933, reverse strandCYP4F11OR10H4: 15,944,299–15,950,350, forward strandOR10H4TPM4: 16,067,021–16,103,011, forward strandTPM4RAB8A: 16,111,653–16,134,235, forward strandRAB8AHSH2D: 16,134,028–16,158,575, forward strandHSH2DCIB3: 16,161,368–16,173,525, reverse strandCIB3FAM32A: 16,185,378–16,192,048, forward strandFAM32AAP1M1: 16,197,854–16,245,906, forward strandAP1M1KLF2: 16,324,613–16,328,685, forward strandKLF2EPS15L1: 16,354,591–16,472,085, reverse strandEPS15L1Diagram of CYP4F2: 13 exons on the reverse strand of chromosome 19Exon 13: 15,878,023–15,878,936, 914 basesExon 12: 15,879,346–15,879,428, 83 basesExon 11: 15,879,604–15,879,668, 65 basesExon 10: 15,879,764–15,879,897, 134 basesExon 9: 15,885,924–15,886,053, 130 basesExon 8: 15,886,242–15,886,308, 67 basesExon 7: 15,889,423–15,889,693, 271 basesExon 6: 15,890,312–15,890,433, 122 basesExon 5: 15,892,309–15,892,436, 128 basesExon 4: 15,892,529–15,892,582, 54 basesExon 3: 15,895,506–15,895,650, 145 basesExon 2: 15,897,414–15,897,612, 199 basesExon 1: 15,898,026–15,898,074, 49 bases1310515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.4 kb of the gene's 20.1 kb; 1,563 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • CPIC and PharmGKB: the alleles, results and medicines.

Cite this page

APA

Dante Labs. (n.d.). CYP4F2 gene: cytochrome P450 family 4 subfamily F member 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/cyp4f2

Vancouver

Dante Labs. CYP4F2 gene: cytochrome P450 family 4 subfamily F member 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cyp4f2

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test