Traits

Traits linked to TGM5

transglutaminase 5

The Human Phenotype Ontology links 13 traits to TGM5, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the integument

Trait	How often it is seen
Cleavage at junction of stratum corneum and stratum granulosum	Always
Scaling skin	Always
Abnormal blistering of the skin	Often (30–79%)
Ichthyosis	Often (30–79%)
Flat, discolored area of skin	Sometimes (5–29%)
Papule	Sometimes (5–29%)
Patchy darkened skin	Sometimes (5–29%)
Skin erosion	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Allergy	Often (30–79%)
Eczema	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Redundant, wrinkled skin of palms	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Redness of skin or mucous membrane	Always

Abnormality of the eye

Trait	How often it is seen
Severe farsightedness	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TGM5 and how often each is seen. Find out more at hpo.jax.org.

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