Traits

Traits linked to RBBP7

RB binding protein 7, chromatin remodeling factor

The Human Phenotype Ontology links 12 traits to RBBP7, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the genitourinary system

Trait	How often it is seen
Decreased testicular size	Always
Leydig cell neoplasia	Always
Male infertility	Always
Non-obstructive azoospermia	Always
Spermatogenesis maturation arrest	Always
Abnormal sperm development	Very often (80–99%)
Absent sperm in semen	Very often (80–99%)
Obstructive azoospermia	Often (30–79%)

Abnormality of the endocrine system

Trait	How often it is seen
Decreased serum testosterone level	Always
Elevated circulating follicle stimulating hormone level	Always
Elevated circulating luteinizing hormone level	Always
Increased circulating gonadotropin level	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to RBBP7 and how often each is seen. Find out more at hpo.jax.org.

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