Traits

Traits linked to PLG

plasminogen

The Human Phenotype Ontology links 28 traits to PLG, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Big calvaria	Always
Pink eye	Always
Dandy-Walker malformation	Often (30–79%)
Gum enlargement	Often (30–79%)
Inflamed gums	Often (30–79%)
Gum disease	Sometimes (5–29%)
Facial puffiness	Not recorded
Recurrent colds	Not recorded
Swollen lip	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormal fallopian tube morphology	Sometimes (5–29%)
Abnormality of the ovary	Sometimes (5–29%)
Kidney inflammation	Sometimes (5–29%)
Kidney stone	Sometimes (5–29%)
Uterine cervix inflammation	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Abnormality of the eye	Very often (80–99%)
Abnormality of vision	Very often (80–99%)
Blindness	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Too much cerebrospinal fluid in the brain	Always
Small cerebellum	Often (30–79%)
Ventriculomegaly	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Angioedema	Not recorded
Laryngeal edema	Not recorded

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Decreased circulating plasminogen concentration	Always

Abnormality of the digestive system

Trait	How often it is seen
Duodenal ulcer	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Abnormality of the middle ear	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Abnormality of the skin	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Generalized decreased muscle tone	Often (30–79%)

Abnormality of the respiratory system

Trait	How often it is seen
Abnormality of the respiratory system	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to PLG and how often each is seen. Find out more at hpo.jax.org.

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