Traits

Traits linked to NRXN1

neurexin 1

The Human Phenotype Ontology links 17 traits to NRXN1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Schizophrenia	Always
Epileptic encephalopathy	Often (30–79%)
Wide based walk	Sometimes (5–29%)
Intellectual disability, severe	Not recorded
Loss of developmental milestones	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Drooling	Not recorded
Protruding tongue	Not recorded
Wide mouth	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Acid reflux	Not recorded
Constipation	Not recorded
Feeding difficulties	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Generalized decreased muscle tone	Not recorded
Low muscle tone	Not recorded
Scoliosis	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Narrowing of pulmonic valve	Not recorded

Abnormality of the eye

Trait	How often it is seen
Cross-eyed	Not recorded

Abnormality of the respiratory system

Trait	How often it is seen
Rapid breathing	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to NRXN1 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test