Traits

Traits linked to MSH3

mutS homolog 3

The Human Phenotype Ontology links 19 traits to MSH3, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	How often it is seen
Adenomatous colonic polyposis	Always
Colorectal polyposis	Very often (80–99%)
Juvenile gastrointestinal polyposis	Very often (80–99%)
Colon cancer	Often (30–79%)
Multiple gastric polyps	Often (30–79%)
Rectal tumor	Often (30–79%)
Stomach cancer	Often (30–79%)
Duodenal polyposis	Sometimes (5–29%)
Gastric adenocarcinoma	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Uterine leiomyoma	Often (30–79%)
Cystic kidney disease	Sometimes (5–29%)
Ovarian cyst	Sometimes (5–29%)
Ovarian dermoid cyst	Sometimes (5–29%)
Endometrial carcinoma	Not recorded

Abnormality of the integument

Trait	How often it is seen
Papilloma	Often (30–79%)
Skin cancer	Often (30–79%)

Abnormality of the breast

Trait	How often it is seen
Breast intraductal papilloma	Often (30–79%)

Abnormality of the endocrine system

Trait	How often it is seen
Thyroid adenoma	Often (30–79%)

Abnormality of the nervous system

Trait	How often it is seen
Astrocytoma	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to MSH3 and how often each is seen. Find out more at hpo.jax.org.

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