Trait

Duodenal polyposis

Presence of multiple polyps in the duodenum.

HPO HP:0004783

Also called: Multiple duodenal polyps
Body system: Abnormality of the digestive system Abnormal tissue mass

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5 genes linked to Duodenal polyposis

Changes in these genes cause rare conditions in which Duodenal polyposis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
APCAPC regulator of Wnt signaling pathway	Very often (80–99%)	In 4 conditions
MSH3mutS homolog 3	Sometimes (5–29%)	In 1 condition
BMPR1Abone morphogenetic protein receptor type 1A	Rarely (1–4%)	In 1 condition
ENGendoglin	Rarely (1–4%)	In 1 condition
SMAD4SMAD family member 4	Rarely (1–4%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Small intestinal polyposis

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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