Traits

Traits linked to MDFIC

MyoD family inhibitor domain containing

The Human Phenotype Ontology links 13 traits to MDFIC, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of prenatal development or birth

Trait	How often it is seen
Fetal ascites	Always
Fetal chylothorax	Always
Fetal pleural effusion	Always
Fetal pericardial effusion	Often (30–79%)
High levels of amniotic fluid	Often (30–79%)

Abnormality of the respiratory system

Trait	How often it is seen
Neonatal respiratory distress	Often (30–79%)
Pleural thickening	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Swelling caused by excess lymph fluid under skin	Always
Nonimmune hydrops fetalis	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Recurrent upper and lower respiratory tract infections	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Inguinal hernia	Often (30–79%)

Abnormality of the genitourinary system

Trait	How often it is seen
Hydrocele testis	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Hyperkeratosis	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to MDFIC and how often each is seen. Find out more at hpo.jax.org.

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