Traits

Traits linked to KLK11

kallikrein related peptidase 11

The Human Phenotype Ontology links 13 traits to KLK11, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the integument

Trait	How often it is seen
Congenital ichthyosiform erythroderma	Always
Parakeratosis	Always
Nail pits	Sometimes (5–29%)
White discoloration of nails	Sometimes (5–29%)
Hyperkeratosis	Not recorded
Itching	Not recorded
Scaling skin	Not recorded
Thickening of upper layer of skin	Not recorded

Abnormality of limbs

Trait	How often it is seen
Diffuse palmoplantar hyperkeratosis	Always
Thickening of the outer layer of the skin of the palms and soles	Always
Thickening of palms and soles	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Redness of skin or mucous membrane	Always

Abnormality of the immune system

Trait	How often it is seen
Red scaly skin caused by inflammatory skin disease	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to KLK11 and how often each is seen. Find out more at hpo.jax.org.

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