Trait

Diffuse palmoplantar hyperkeratosis

Diffuse abnormal thickening of the skin on the palms and soles.

HPO HP:0007447

Also called: Diffuse palmoplantar keratoderma, Hyperkeratosis, diffuse palmoplantar
Body system: Abnormality of limbs Abnormality of the integument

Read the genes linked to Diffuse palmoplantar hyperkeratosis, and the rest of your genome, with one test.

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10 genes linked to Diffuse palmoplantar hyperkeratosis

Changes in these genes cause rare conditions in which Diffuse palmoplantar hyperkeratosis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
JUPjunction plakoglobin	Always	In 1 condition
KLHL24kelch like family member 24	Always	In 1 condition
KLK11kallikrein related peptidase 11	Always	In 1 condition
AQP5aquaporin 5	Very often (80–99%)	In 2 conditions
KRT1keratin 1	Very often (80–99%)	In 3 conditions
SNAP29synaptosome associated protein 29	Very often (80–99%)	In 1 condition
KRT16keratin 16	Often (30–79%)	In 1 condition
KRT9keratin 9	Often (30–79%)	In 1 condition
SLURP1secreted LY6/PLAUR domain containing 1	Often (30–79%)	In 1 condition
RHBDF2rhomboid 5 homolog 2	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Thickening of the outer layer of the skin of the palms and soles

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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