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Gene

HOMER2

homer scaffold protein 2

Summary

Cytogenetic location
15q25.2
Coordinates
Chromosome 15: 82,848,983–82,952,720 (GRCh38)
Exons
9 exons across 103.7 kb
Protein
343 amino acids
Also known as
CPD, Cupidin, Vesl-2, HOMER-2B, HOMER-2, HOMER-2A, DFNA68
MANE Select transcript
ENST00000450735.7NM_004839.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Hearing Loss and Deafness

    • Autosomal Dominant Nonsyndromic Hearing LossAutosomal dominant

      Autosomal dominant form of nonsyndromic deafness.

      • 2 GenCC submitters rate it definitive or strong
    • Nonsyndromic Genetic Hearing Loss

      One of 97 genes linked to it

      Inherited hearing loss without other medical features, including the common recessive forms caused by GJB2, OTOF, SLC26A4, STRC and many other genes, as well as dominant, X-linked and mitochondrial forms.

      • ClinGen rates the link moderate
      • 2 GenCC submitters rate it definitive or strong
      Actionability

      Knowing the genetic cause can guide hearing support and cochlear implant decisions, gene-therapy trial eligibility (for example OTOF) and family counselling.

How HOMER2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where HOMER2 sits. HOMER2 and 13 genes near it on chromosome 15, from 82,400,852 to 83,400,851.Chromosome 1515q25.2p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.382.6 Mb82.8 Mb83 Mb83.2 Mb83.4 MbGOLGA6L9: 82,429,816–82,439,153, forward strandGOLGA6L9RPS17: 82,536,592–82,540,622, reverse strandRPS17: 82,536,788–82,573,194, reverse strandCPEB1: 82,543,201–82,648,861, reverse strandCPEB1AP3B2: 82,659,281–82,710,112, reverse strandAP3B2FSD2: 82,755,362–82,806,148, reverse strandFSD2WHAMM: 82,809,581–82,836,108, forward strandWHAMMHOMER2: 82,848,983–82,952,720, reverse strandHOMER2RAMAC: 82,986,199–82,991,057, forward strandRAMACC15orf40: 82,988,364–83,011,647, reverse strandC15orf40BTBD1: 83,016,423–83,067,412, reverse strandBTBD1TM6SF1: 83,107,369–83,161,068, forward strandTM6SF1HDGFL3: 83,112,738–83,208,424, reverse strandHDGFL3BNC1: 83,255,884–83,284,664, reverse strandBNC1Diagram of HOMER2: 9 exons on the reverse strand of chromosome 15Exon 9: 2 known disease-causing sitesExon 9: 82,848,983–82,849,903, 921 basesExon 8: 82,851,151–82,851,231, 81 basesExon 7: 82,852,142–82,852,252, 111 basesExon 6: 82,854,644–82,854,800, 157 basesExon 5: 82,859,029–82,859,135, 107 basesExon 4: 82,864,167–82,864,259, 93 basesExon 3: 82,875,273–82,875,404, 132 basesExon 2: 82,892,685–82,892,841, 157 basesExon 1: 82,952,531–82,952,720, 190 bases9864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 103.7 kb; 1,032 of those bases code for the protein.

Sequencing HOMER2

2Low

How hard HOMER2 is to sequence with short reads, out of 100

  • Mappability0%
  • Homology0%
  • Repeats1.6%
  • GC content13%
  • Reference coverage0%

2

positions in HOMER2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 103.7 kb of HOMER2, introns included, not only the 1.9 kb of exons.

Genes linked to the same conditions

Traits linked to HOMER2

The Human Phenotype Ontology lists these as features of the rare conditions HOMER2 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). HOMER2 gene: homer scaffold protein 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/homer2

Vancouver

Dante Labs. HOMER2 gene: homer scaffold protein 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/homer2

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