Traits

Traits linked to CD27

CD27 molecule

The Human Phenotype Ontology links 23 traits to CD27, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Lymphoproliferative disorder	Often (30–79%)
Aplastic anemia	Sometimes (5–29%)
Cancer of lymphatic system	Sometimes (5–29%)
Hemophagocytosis	Sometimes (5–29%)
Hodgkin lymphoma	Sometimes (5–29%)
Low blood cell count	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
EBV encephalitis	Sometimes (5–29%)
EBV meningitis	Sometimes (5–29%)
Infection in blood stream	Sometimes (5–29%)
Recurrent pneumonia	Sometimes (5–29%)
Severe varicella zoster infection	Sometimes (5–29%)
Recurrent infections	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Increased spleen size	Always
Swollen lymph nodes	Often (30–79%)
Enlarged liver and spleen	Sometimes (5–29%)

Abnormal cellular phenotype

Trait	How often it is seen
Decreased circulating antibody level	Often (30–79%)
Decreased mitogen-induced T-cell proliferation	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Enlarged liver	Always
Accumulation of fluid in the abdomen	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Fever	Often (30–79%)
Persistent EBV viremia	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Mouth sore	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Uveitis	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CD27 and how often each is seen. Find out more at hpo.jax.org.

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