Traits

Traits linked to ADH1C

alcohol dehydrogenase 1C (class I), gamma polypeptide

The Human Phenotype Ontology links 25 traits to ADH1C, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Abnormal autonomic nervous system physiology	Sometimes (5–29%)
Hallucinations	Sometimes (5–29%)
Addictive alcohol use	Not recorded
Balance impairment	Not recorded
Dementia	Not recorded
Depression	Not recorded
Difficulty articulating speech	Not recorded
Difficulty sleeping	Not recorded
Dystonia	Not recorded
Lewy bodies	Not recorded
Loss of brain cells	Not recorded
Micrographia	Not recorded
Parkinsonism	Not recorded
Personality changes	Not recorded
Resting tremor	Not recorded
Short stepped shuffling walk	Not recorded
Slow movements	Not recorded
Substantia nigra gliosis	Not recorded
Tremor	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Constipation	Not recorded
Poor swallowing	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Expressionless face	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Urinary urgency	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Rigidity	Not recorded

Abnormality of the voice

Trait	How often it is seen
Weak voice	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ADH1C and how often each is seen. Find out more at hpo.jax.org.

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