Polygen risikoscore for levetid (kvinder)

En polygen score for All-cause mortality (female)

Genetiske varianter

4.122

Metode

Composite PRS (component scores combined by log(HR))

Udviklet på baggrund af undersøgelser af

Europæisk 91%, Ikke oplyst 6%, Østasiatisk 1%, Afrikansk 1%, Asiatisk 0%, Sydasiatisk 0%, Hispansk eller latinamerikansk 0%

Udviklet i

Europæisk 100%

Evalueret i

Europæisk 100%

Referencer

1. Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, 2012. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet
2. Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, 2013. Discovery and refinement of loci associated with lipid levels. Nat Genet
3. Li M, Li Y, Weeks O, Mijatovic V, Teumer A, Huffman JE, 2017. SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J Am Soc Nephrol
4. Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, 2018. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet
5. Yengo L, Sidorenko J, Kemper KE, Zheng Z, Wood AR, Weedon MN, 2018. Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry. Hum Mol Genet
6. Liu M, Jiang Y, Wedow R, Li Y, Brazel DM, Chen F, 2019. Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nat Genet
7. Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, 2019. Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Nat Commun

Andre længdevitalitet og aldring risk scores

• Aldersrelateret makuladegeneration
• Ansigtsaldring
• Glaukom
• Knogletæthed
• Lang levetid
• Levetid (mænd)