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Risk score · Longevity & ageing

Lifespan Polygenic Score (Women)

A score for women that combines genetic influences on many causes of death, from heart disease to smoking behaviour, into one estimate of all-cause mortality.

A risk score adds up many common variants, each with a small effect, into an estimate of genetic predisposition. It is not a diagnosis.

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A polygenic score for All-cause mortality (female)

Genetic variants

4,122

Method

Composite PRS (component scores combined by log(HR))

Built from studies of

European 91%, Not reported 6%, East Asian 1%, African 1%, Asian 0%, South Asian 0%, Hispanic or Latin American 0%

Developed in

European 100%

Evaluated in

European 100%

Published

Meisner A et al. (2020). Combined Utility of 25 Disease and Risk Factor Polygenic Risk Scores for Stratifying Risk of All-Cause Mortality. Am J Hum Genet.

The score in the PGS Catalog →

References

  1. Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, 2012. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet
  2. Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, 2013. Discovery and refinement of loci associated with lipid levels. Nat Genet
  3. Li M, Li Y, Weeks O, Mijatovic V, Teumer A, Huffman JE, 2017. SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J Am Soc Nephrol
  4. Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, 2018. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet
  5. Yengo L, Sidorenko J, Kemper KE, Zheng Z, Wood AR, Weedon MN, 2018. Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry. Hum Mol Genet
  6. Liu M, Jiang Y, Wedow R, Li Y, Brazel DM, Chen F, 2019. Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nat Genet
  7. Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, 2019. Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Nat Commun

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One kit, sent to your home. Your entire genome sequenced at the clinical standard used for diagnostic decisions. Physician-ready reports delivered to your Genome Manager in 6–8 weeks — permanent and updated as science advances.

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