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Risk score · Immune & inflammatory

Systemic Sclerosis Polygenic Risk Score

Systemic sclerosis, also called scleroderma, is a rare autoimmune disease that causes scarring and hardening of the skin and can affect internal organs. It is much more common in women.

A risk score adds up many common variants, each with a small effect, into an estimate of genetic predisposition. It is not a diagnosis.

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Limitations

  • A polygenic score does not include sex hormones, which are thought to shape how the disease differs between women and men.

References

  1. Pătrîntașu DE, Sárközi HK, Lupușor E, Vlangăr IE, Rotariu GM, Rența IA et al., 2023. A Multidisciplinary Approach as a Goal for the Management of Complications in Systemic Scleroderma: A Literature Review and Case Scenario
  2. Zhong L, Pope M, Shen Y, Hernandez JJ, Wu L, 2019. Prevalence and incidence of systemic sclerosis: A systematic review and meta-analysis
  3. Toitou M, Iacovantuono M, Sauer G, Mihai C, Chimenti MS, Distler O et al., 2025. Sex differences in systemic sclerosis: from pathogenesis to clinical manifestations and treatment

Other immune & inflammatory risk scores

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Free shipping · Results in 6–8 weeks

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