Skip to content
Use your HSA or FSA funds

Trait

Inverted CD4:CD8 ratio

CD4:CD8 ratio less than 1, measured either as proportion of total CD3+ T cells, or in absolute numbers per microliter. These are usually measured within the TCR alpha/beta positive population. Normally there are relatively more CD4+ than CD8+ T cells.

HPO HP:0033222

Summary

Also called
Decreased CD4:CD8 ratio, Inverted CD4/CD8 ratio
Body system
Abnormality of blood and blood-forming tissuesAbnormality of the immune system

15 genes linked to Inverted CD4:CD8 ratio

Changes in these genes cause rare conditions in which Inverted CD4:CD8 ratio is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
AP3B1adaptor related protein complex 3 subunit beta 1AlwaysIn 1 condition
CASP8caspase 8AlwaysIn 1 condition
CD40LGCD40 ligandAlwaysIn 1 condition
IKZF2IKAROS family zinc finger 2AlwaysIn 1 condition
IL2RAinterleukin 2 receptor subunit alphaAlwaysIn 1 condition
ITPR3inositol 1,4,5-trisphosphate receptor type 3AlwaysIn 1 condition
MAGT1magnesium transporter 1AlwaysIn 1 condition
MAN2B2mannosidase alpha class 2B member 2AlwaysIn 1 condition
RFXAPregulatory factor X associated proteinAlwaysIn 1 condition
WASWASP actin nucleation promoting factorAlwaysIn 1 condition
CTPS1CTP synthase 1Often (30–79%)In 1 condition
DEF6DEF6 guanine nucleotide exchange factorOften (30–79%)In 1 condition
IL2RBinterleukin 2 receptor subunit betaOften (30–79%)In 1 condition
UNC119unc-119 lipid binding chaperoneOften (30–79%)In 1 condition
GATA2GATA binding protein 2Sometimes (5–29%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal CD4:CD8 ratio

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test