Traits

Traits linked to ZFP57

ZFP57 zinc finger protein

The Human Phenotype Ontology links 23 traits to ZFP57, by body system: features seen in people with one of the gene's rare conditions.

Laboratory abnormality

Trait	How often it is seen
Dehydration	Very often (80–99%)
High blood sugar	Very often (80–99%)
Maturity-onset diabetes of the young	Often (30–79%)
Transient neonatal diabetes mellitus	Often (30–79%)
Diabetic ketoacidosis	Rarely (1–4%)

Growth abnormality

Trait	How often it is seen
Prenatal growth deficiency	Very often (80–99%)
Small for gestational age	Very often (80–99%)
Faltering weight	Sometimes (5–29%)
Severe faltering weight	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Abnormality of the nervous system	Sometimes (5–29%)
Epilepsy	Sometimes (5–29%)
Neurodevelopmental delay	Sometimes (5–29%)

Abnormality of the endocrine system

Trait	How often it is seen
Hypoinsulinemia	Very often (80–99%)
Underactive thyroid	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormality of the kidney	Sometimes (5–29%)
Urinary tract abnormalities	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Abnormally large tongue	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Abnormality of limbs	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormality of the heart	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Umbilical hernia	Often (30–79%)

Abnormality of the ear

Trait	How often it is seen
Hearing impairment	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Autoimmune antibody positivity	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ZFP57 and how often each is seen. Find out more at hpo.jax.org.

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