Traits

Traits linked to UFM1

ubiquitin fold modifier 1

The Human Phenotype Ontology links 14 traits to UFM1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Absent speech development	Not recorded
Degeneration of cerebellum	Not recorded
Degeneration of cerebrum	Not recorded
Dystonia	Not recorded
Epilepsy	Not recorded
Intellectual disability	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Generalized decreased muscle tone	Not recorded
Involuntary muscle stiffness, contraction, or spasm	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties	Not recorded

Abnormality of the ear

Trait	How often it is seen
Hearing impairment	Rarely (1–4%)

Abnormality of the eye

Trait	How often it is seen
Blindness	Rarely (1–4%)

Abnormality of the respiratory system

Trait	How often it is seen
Respiratory function loss	Not recorded

Growth abnormality

Trait	How often it is seen
Growth delay	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to UFM1 and how often each is seen. Find out more at hpo.jax.org.

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