Traits

Traits linked to TNF

tumor necrosis factor

The Human Phenotype Ontology links 13 traits to TNF, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Fear of loud sounds	Not recorded
Migraine with aura	Not recorded
Migraine without aura	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Enlarged thymus	Often (30–79%)
Shock	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Nausea	Not recorded
Vomiting	Not recorded

Abnormality of the immune system

Trait	How often it is seen
Pulmonary tuberculosis	Always
Asthma	Not recorded

Abnormality of the respiratory system

Trait	How often it is seen
Airway hyperresponsiveness	Not recorded
Bronchoconstriction	Not recorded

Abnormality of the eye

Trait	How often it is seen
Extreme sensitivity of the eyes to light	Not recorded

Laboratory abnormality

Trait	How often it is seen
Fluid around lungs	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TNF and how often each is seen. Find out more at hpo.jax.org.

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