Traits

Traits linked to HAMP

hepcidin antimicrobial peptide

The Human Phenotype Ontology links 25 traits to HAMP, by body system: features seen in people with one of the gene's rare conditions.

Laboratory abnormality

Trait	How often it is seen
Elevated serum ferritin	Always
Elevated transferrin saturation	Always
Abnormality of iron homeostasis	Very often (80–99%)
Diabetes mellitus	Often (30–79%)
High liver enzymes	Often (30–79%)
Elevated circulating iron concentration	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Hepatic fibrosis	Always
Scar tissue replaces healthy tissue in the liver	Always
Excessive buildup of connective tissue and scarring of liver at birth	Very often (80–99%)
Abnormality of endocrine pancreas physiology	Sometimes (5–29%)
Enlarged liver	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Stretched and thinned heart muscle	Often (30–79%)
Cardiac failure	Not recorded
Disease of the heart muscle	Not recorded
Increased spleen size	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Disease of the joints	Often (30–79%)
Muscle weakness	Often (30–79%)
Osteoporosis	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Previous menstrual periods stop	Always
Difficulty getting a full erection	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Patchy darkened skin	Always
Generalized hyperpigmentation	Often (30–79%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Low number of red blood cells or hemoglobin	Not recorded

Abnormality of the endocrine system

Trait	How often it is seen
Decreased activity of gonads	Always

Abnormality of the nervous system

Trait	How often it is seen
Lethargy	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to HAMP and how often each is seen. Find out more at hpo.jax.org.

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