Traits

Traits linked to H4C11

H4 clustered histone 11

The Human Phenotype Ontology links 21 traits to H4C11, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Depressed nasal bridge	Always
Downturned corners of mouth	Always
Fullness around the eyes	Always
Highly arched eyebrow	Always
Short philtrum	Always
Upward slanting of the opening between the eyelids	Always
Wide mouth	Always

Abnormality of the nervous system

Trait	How often it is seen
Absent speech development	Always
Autism spectrum disorder	Always
Delayed speech and language development	Always
Global developmental delay	Always
Intellectual disability	Always

Abnormality of the eye

Trait	How often it is seen
Inward turning cross eyed	Always
Oculomotor apraxia	Always
Wide-set eyes	Always

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Always
Muscle degeneration	Always

Growth abnormality

Trait	How often it is seen
Growth delay	Always
Short stature	Always

Abnormality of limbs

Trait	How often it is seen
Dropped arches	Always

Abnormality of the genitourinary system

Trait	How often it is seen
Hypospadias	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to H4C11 and how often each is seen. Find out more at hpo.jax.org.

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