Traits

Traits linked to GRK1

G protein-coupled receptor kinase 1

The Human Phenotype Ontology links 13 traits to GRK1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the eye

Trait	How often it is seen
ERG: Reduced dark-adapted b-wave amplitude	Very often (80–99%)
Mizuo phenomenon	Very often (80–99%)
Night blindness since birth	Very often (80–99%)
Abnormality of refraction	Sometimes (5–29%)
Close sighted	Sometimes (5–29%)
Macular degeneration	Sometimes (5–29%)
Cross-eyed	Rarely (1–4%)
Double vision	Rarely (1–4%)
Involuntary, rapid, rhythmic eye movements	Rarely (1–4%)
Rod-cone dystrophy	Rarely (1–4%)
Visual impairment	Rarely (1–4%)
Color blindness	Not recorded
Partial loss of field of vision	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to GRK1 and how often each is seen. Find out more at hpo.jax.org.

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